Répertoire du corps professoral
Jorge Soliz
Professeur titulaire
jorge.soliz@criucpq.ulaval.ca
Living Without Air: How Highlanders Redefine the Boundaries of Aerobic Life
Programme: Subventions à la découverte SD (individuelles et d'équipe)
Organisme(s) subventionnaire(s): Conseil de recherches en sciences naturelles et génie Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 avril 2026
au 31 mars 2031
FGR-Cardiorespiratory Hypoxia Resilience: Molecular and Physiological Insights from High-Altitude Adapted Populations
Programme: Fonds général de recherche du CRSNG
Organisme(s) subventionnaire(s): Université Laval - Fonds internes
Type de financement: Subvention
Établissement tête: Université Laval
Du 22 juillet 2025
au 21 janvier 2027
Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice
Programme: Subvention Projet
Organisme(s) subventionnaire(s): Instituts de recherche en santé du Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 1 octobre 2022
au 30 septembre 2027
Financements des 2 dernières années
Collaboration avec l’Institut bolivien de biologie de haute altitude
Programme: Programme de mobilité enseignante pour la création de partenariats
Organisme(s) subventionnaire(s): Affaires mondiales Canada
Type de financement: Subvention
Établissement tête: Université Laval
Du 11 avril 2024
au 31 mai 2025
Encadrements terminés dans les 5 dernières années
Publications des 5 dernières années
Neonatal stress is associated with region‐specific changes in mitochondrial respiration and sex‐dependent respiratory instability in adulthood The Journal of Physiology, 2026/11/01. Antonia Vallejo Puerta, Lida Sanchez, Fernanda Aliaga‐Raduan, Pablo Iturri‐Soliz, Richard Kinkead, Aida Bairam, Edith M. Schneider Gasser, Jorge Soliz. DOI 10.1113/JP290807
RAPTOR-targeted Antisense Oligonucleotides Restrict Pathological mTORC1 Activity in GATOR1-dependent Disease 2026/10/04. Imane Hadj-Aissa, Maéline Muller, Antoine Desmeules, Laetitia Marcadet, Tristan Lachance-Brulotte, Nadine Morin, Marc-Étienne Huot, Jorge Soliz, Chantelle F. Sephton, Paul A. Dutchak. DOI 10.64898/2026.09.30.755052
The high-altitude baby: Neonatal development and survival in hypoxic environments Respiratory Physiology & Neurobiology, 2026/08. Amed Soliz, Jorge Soliz. DOI 10.1016/j.resp.2026.104609
GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling EMBO Reports, 2026/07/03. Imane Hadj-Aissa, Maéline Muller, Jorge Soliz, Chantelle F Sephton, Paul A Dutchak. DOI 10.1038/s44319-026-00846-w
High altitude limits the biogeography of common rats but not house mice Scientific Reports, 2026/05/20. Christian Arias-Reyes, Favio Carvajal-Rodriguez, Jorge Soliz, Vincent Joseph. DOI 10.1038/s41598-026-53527-y
Clinical exposure thresholds associated with retinopathy of prematurity in preterm infants born at high altitude Respiratory Physiology & Neurobiology, 2026/05. Monica Villa Guillén, Martha Wilma Quispe Copa, Dina Villanueva García, Christian Arias-Reyes, Jorge Soliz. DOI 10.1016/j.resp.2026.104561
Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity Brain, 2026/02/07. Laetitia Marcadet, Mari Carmen Pelaez, Antoine Desmeules, Jeanne Serrano, Zhan Cheng, C Sahara Khademullah, Elahe Parham, Jaimee Kennedy, Claire Troakes, Caroline Vance, Jorge Soliz, Heather D Durham, Liang Li, Paul A Dutchak, Chantelle F Sephton. DOI 10.1093/brain/awaf328
Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma Lung, 2025/12. Sébastien Hecht, Andrés Rojas-Ruiz, Magali Boucher, Cyndi Henry, Jorge Soliz, Ynuk Bossé. DOI 10.1007/s00408-025-00840-4
Altitude-specific neurocritical care: A case study in the management of traumatic brain injury Medical Reports, 2025/12. Fausto Maldonado-Coronel, Catty Castillo-Caicedo, Antonio Viruez-Soto, Roger Huanca-Payehuanca, Amílcar Tinoco-Solórzano, Daniel Molano-Franco, Christian Arias-Reyes, Jorge Soliz. DOI 10.1016/j.hmedic.2025.100385
Methacholine hyperresponsiveness in mice with house dust mite‐induced lung inflammation is not associated with excessive airway constriction ex vivo Experimental Physiology, 2025/09. Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Percival Graham, Jorge Soliz, Ynuk Bossé. DOI 10.1113/ep092522
High altitude induces a shift from complex I to complex II in the brain mitochondria of newborn and adult mice Journal of Experimental Biology, 2025/08/15. Maud Demarest, Fernanda Aliaga-Raduan, Christian Arias-Reyes, Marcelino Gonzales, Edith M. Schneider Gasser, Jorge Soliz, Vincent Joseph. DOI 10.1242/jeb.250422
Living at high altitude induces a switch from complex I to complex II in hepatic mitochondria of mice during postnatal development Physiology, 2025/05. Maud Demarest, Fernanda Aliaga-Raduan, Marcelino Gonzales, Edith Schneider-Gasser, Jorge Soliz, Vincent Joseph. DOI 10.1152/physiol.2025.40.s1.0566
Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs Frontiers in Physiology, 2025/01/15. Daniel Molano-Franco, Joan Ramon Masclans Enviz, Antonio Viruez-Soto, Mario Gomez, Harvey Rojas, Edgar Beltran, Victor Nieto, Fernanda Aliaga-Raduan, Pablo Iturri, Christian Arias-Reyes, Jorge Soliz. DOI 10.3389/fphys.2024.1520650
Low and sustained doses of erythropoietin prevent preterm infants from intraventricular hemorrhage Respiratory Physiology & Neurobiology, 2025/01. Diana Andrea Arias Fernández, Héctor Alfonso Romero Diaz, Alan David Figueroa Garnica, Pablo Iturri-Soliz, Christian Arias-Reyes, Edith Mariane Schneider Gasser, Jorge Soliz. DOI 10.1016/j.resp.2024.104363
Lung Volumes in a Mouse Model of Pulmonary Allergic Inflammation Lung, 2024/10. Andrés Rojas-Ruiz, Magali Boucher, Cyndi Henry, Rosalie Packwood, Jorge Soliz, Ynuk Bossé. DOI 10.1007/s00408-024-00730-1
Pneumonia is the Leading Cause of Death from Respiratory Diseases at High Altitude In La Paz, Bolivia International Journal of Innovative Research in Medical Science, 2024/02/15. Gonzales Marcelino, Casto Navia, Carlos Tamayo, Martin Villarroel, Aida Bairam, Lida Sanchez, Christian Arias-Reyes, Jorge Soliz. DOI 10.23958/ijirms/vol09-i02/1827
The ultrasound-based cardiac output monitoring is a useful tool to define baseline hemodynamic parameters in healthy permanent residents at high altitude: results of a monocentric pilot study Frontiers in Physiology, 2024/01/17. Antonio Viruez-Soto, Daniel Molano-Franco, Alfredo Merino-Luna, Aida Bairam, Fernanda Aliaga-Raduán, Lida Sanchez, Christian Arias-Reyes, Jorge Soliz. DOI 10.3389/fphys.2023.1297872
Impact of High-Flow Nasal Cannula Use in Subjects With COVID-19 ARDS at High Altitudes: Clinical Presentation and Prognostic Factors Respiratory Care, 2024/01. Daniel Molano-Franco, Antonio Viruez-Soto, Mario Gomez, Edgar Beltran, Mario Villabon, Angela Sosa, Leidy Ortiz, Estefania Orozco, Alejandra Hurtado, Lida Sanchez, Christian Arias-Reyes, Jorge Soliz, Joan R Masclans. DOI 10.4187/respcare.10839
Dysfunctional mitochondria in the rostral ventrolateral medulla as a novel mechanism to explain early life stress-related sleep apneas in adult mice Journal of the Neurological Sciences, 2023/12. Lida Sanchez Sanchez, Aida Bairam, Jorge Soliz. DOI 10.1016/j.jns.2023.121170
Lung stiffness of C57BL/6 versus BALB/c mice Scientific Reports, 2023/10/14. Andrés Rojas-Ruiz, Magali Boucher, Rebecka Gill, Louis Gélinas, Fun-Qun Tom, Liah Fereydoonzad, Percival Graham, Jorge Soliz, Ynuk Bossé. DOI 10.1038/s41598-023-44797-x
Neutrophil/Lymphocyte Ratio (NLR) and Lym-phocyte/CRP ratio (LCR) are Reliable Pre-dictors of Adverse Out-comes in High-Altitude COVID-19 Patients Medical Research Archives, 2023/08/30. Rosalinda Jimenez-Aguilar, Alfredo Merino-Luna, Christian Arias-Reyes, Maria Paola Lozada-Mata, Willebaldo Tenorio-Gutierrez, Martin Romero Martinez, Enrique Duenas, Antonio Viruez-Soto, Daniel Molano-Franco, Gustavo Zubieta-Calleja, Natalia Zubieta-DeUrioste, Jose Antonio Carmona Suazo, Amilcar Tinoco-Solorzano, Lida Sanchez, Jorge Soliz. DOI 10.18103/mra.v11i8.4300
COVID-19 Mortality Is Attenuated at High Tropical and Subtropical Altitude: An Observational Study of a Database Covering Five Latin American Countries Medical Research Archives, 2023/08/30. Natalia Zubieta-DeUrioste, Christian Arias-Reyes, Lida Sanchez, Nestor Freddy Armijo-Subieta, Alfredo Merino-Luna, Ivan Solarte, Raffo Escalante-Kanashiro, Jose Antonio Carmona-Suazo, Enrique Maravi Poma, Rosalinda Jimenez-Aguilar, Jose M. Calle-Aracena, Alberto Lopez-Bascope, Roberto Vera, Rafaela Zubieta-DeUrioste, Ninoska Rossel, Yeshua Peña-Y-Lilio, Gary Chambi-Quilla, Luis Herrera-Leon, Santiago Garrido-Salazar, Francisco Ney Villacorta Cordova, Fausto Vinicio Maldonado Coronel, Elisabeth Deindl, Ricki Sheldon, Roberto Alfonso Accinelli, Edith M Schneider-Gasser, Jorge Soliz, Gustavo Zubieta-Calleja. DOI 10.18103/mra.v11i8.4299
The Brain at High Altitude: From Molecular Signaling to Cognitive Performance International Journal of Molecular Sciences, 2023/06/15. Mostafa A. Aboouf, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M. Schneider Gasser. DOI 10.3390/ijms241210179
<i>Malat1</i> deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli. Frontiers in physiology, 2022/08/29. Jorge Soliz, Sallé-Lefort S, Miard S, Henry C, Arias-Reyes C, Marcouiller F, Beaulieu MJ, Aubin S, Lechasseur A, Jubinville É, Marsolais D, Morissette MC, Joseph V, Soliz J, Bossé Y, Picard F. DOI 10.3389/fphys.2022.949378
Corrigendum: Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies. Frontiers in physiology, 2022/07/08. Jorge Soliz, Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, Kinkead R. DOI 10.3389/fphys.2022.964673
Hypoxia Inducible Factor is partially involved in mitochondrial and metabolic responses to hypoxia in rats DEMAREST Maud <sup>1</sup> , MARCOUILLER François <sup>1</sup> , SOLIZ Jorge <sup>1</sup> , JOSEPH Vincent <sup>1</sup> <sup>1</sup> Institut universitaire de cardiologie et de pneumologie, Université Laval, Québec The FASEB Journal, 2022/05. Maud M. Demarest, François Marcouiller, Jorge Soliz, Vincent Joseph. DOI 10.1096/fasebj.2022.36.s1.r2976
Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes. Respiratory physiology & neurobiology, 2022/02/10. Jorge Soliz, Viruez-Soto A, Arias S, Casas-Mamani R, Rada-Barrera G, Merino-Luna A, Molano-Franco D, Tinoco-Solorzano A, Marques DA, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Soliz J. DOI 10.1016/j.resp.2022.103868
Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies. Frontiers in physiology, 2021/12/24. Jorge Soliz, Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, Kinkead R. DOI 10.3389/fphys.2021.781662
Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress. Frontiers in physiology, 2021/12/20. Jorge Soliz, Elliot-Portal E, Arias-Reyes C, Laouafa S, Tam R, Kinkead R, Soliz J. DOI 10.3389/fphys.2021.701344
Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats Frontiers in Pharmacology, 2021/09/14. Christian Arias-Reyes, Sofien Laouafa, Natalia Zubieta-DeUrioste, Vincent Joseph, Aida Bairam, Edith M. Schneider Gasser, Jorge Soliz. DOI 10.3389/fphar.2021.727326
Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice. Communications biology, 2021/08/05. Jorge Soliz, Jacobs RA, Aboouf MA, Koester-Hegmann C, Muttathukunnel P, Laouafa S, Arias-Reyes C, Thiersch M, Soliz J, Gassmann M, Schneider Gasser EM. DOI 10.1038/s42003-021-02465-8
Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients. PloS one, 2021/08/03. Jorge Soliz, Leon-Abarca JA, Portmann-Baracco A, Bryce-Alberti M, Ruiz-Sánchez C, Accinelli RA, Soliz J, Gonzales GF. DOI 10.1371/journal.pone.0255144
Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level. Respiratory physiology & neurobiology, 2021/06/02. Viruez-Soto A, López-Dávalos MM, Rada-Barrera G, Merino-Luna A, Molano-Franco D, Tinoco-Solorozano A, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Soliz J. DOI 10.1016/j.resp.2021.103709
Cerebral erythropoietin promotes sex dependent prevention of disrupted neural control of respiration induced by neonatal stress The FASEB Journal, 2021/05. Christian Arias‐Reyes, Elizabeth Elliot‐Portal, Sofien Laouafa, Rose Tam, Richard Kinkead, Jorge Soliz. DOI 10.1096/fasebj.2021.35.s1.03860
Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent. PloS one, 2021/03/29. Arias-Reyes C, Carvajal-Rodriguez F, Poma-Machicao L, Aliaga-Raduán F, Marques DA, Zubieta-DeUrioste N, Accinelli RA, Schneider-Gasser EM, Zubieta-Calleja G, Dutschmann M, Soliz J. DOI 10.1371/journal.pone.0237294
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia. Frontiers in physiology, 2021/03/12. Jorge Soliz, Arias-Reyes C, Soliz J, Joseph V. DOI 10.3389/fphys.2021.647822
Re: "Mortality Attributed to COVID-19 in High-Altitude Populations" by Woolcott and Bergman. High altitude medicine & biology, 2021/02/09. Jorge Soliz, Zubieta-Calleja G, Merino-Luna A, Zubieta-DeUrioste N, Armijo-Subieta NF, Soliz J, Arias-Reyes C, Escalante-Kanashiro R, Carmona-Suazo JA, López-Bascope A, Calle-Aracena JM, Epstein M, Maravi E. DOI 10.1089/ham.2020.0195
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